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The most frequent group of homogeneously defined patients with lateralized lesions has been patients with temporal lobe epilepsy. Data are presented for 12 separate samples in Table 8.6, most of whom were tested postoperatively following removal of the afflicted temporal lobe. For some of these samples, data were presented that permitted evaluation of V P discrepancies both before and after the lobectomy. Basic Findings for More than 400 Patients with Epilepsy Patients with temporal lobe epilepsy displayed predictable V P differences based on the side that the lesion was located. Because one sample comprised only children with epilepsy (Fedio & Mirsky, 1969), aggregated data are presented both with and without this young sample. Regardless of the inclusion of children, patients with left lesions had P > V by about 6 points, and those with right lesions had V > P by about 21 2 points. Because these composite values are based on about 500 patients, the results are probably generalizable to other samples of patients with temporal lobe epilepsy. These studies have the advantage of being confined to a reasonably specific part of each

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The Psychological Corporation (1997, Tables 4.40 and 4.42) included postoperative data on 4 Verbal and 3 Performance subtests for 27 patients with temporal lobe epilepsy, 15 who had a left lobectomy (mean age = 32.5; 73.3% female; 93.3% Caucasian; 73.3% with at least some college) and 12 who had a right lobectomy (mean age = 30.5; 50% female; 58.3% Caucasian, 33.3% African American, 8.3% Hispanic; 75% with at least some college). The following WAIS-III subtests were administered to the 27 patients: Verbal (Vocabulary, Similarities, Digit Span, LetterNumber Sequencing) and Performance (Digit Symbol-Coding, Block Design, Matrix Reasoning). The patients with left lesions, who had a left lobectomy, earned a mean Performance scaled score of 10.0 compared to a mean of 8.3 on the Verbal subtests. This substantial difference is in the predicted direction of P > V. The patients with right lesions who had a right lobectomy averaged 9.8 on Verbal subtests and 10.2 on Performance subtests, a slight V > P pattern that is opposite to prediction. The predicted finding for patients with left lobectomy is consistent with previous research, as is the more pronounced result for patients with epilepsy who have left versus right temporal lesions. However, the opposite profile for patients with right lobectomies is not consistent with most previous re-

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search, though it does mirror Chelune et al. s (1993) results. The Psychological Corporation (1997) administered two subtests from three of the factor indexes plus a single Processing Speed task. Mean scaled scores were computed for each of the three indexes for each patient sample; these means are shown below, with the mean Digit Symbol-Coding scaled score serving as the estimate of PSI.

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Note that the patients with right lesions performed better on all four factors. However, the differences were substantial for VCI and WMI (consistent with predictions, because both of these scales are composed of Verbal subtests) and trivial for POI and PSI. The Psychological Corporation (1997) also administered the WMS-III to the patient sample and found predictable patterns for both groups: Patients with left lesions had higher scores on visual than auditory tasks, both immediate and delayed, whereas patients with right lesions performed better on auditory than visual memory tasks. Preoperative versus Postoperative V P Discrepancies Table 8.7 shows the results of three studies of patients with temporal lobe epilepsy that permitted a comparison of preoperative and postoperative scores on the Wechsler Verbal and Performance scales. The samples differed greatly in the mean interval between the temporal lobectomy surgery and the posttest (means of about 1 month, 1 year, and 3 years). Nevertheless, in nearly all samples V P differences prior to surgery were in the predictable directions based on the side of the lesion, but these discrepancies were small; subsequent to surgery, V P differences were still mostly in the predicted directions, but the re-

moval of the left or right temporal lobe apparently led to a substantial increase in mean V P discrepancies Across samples, with about 100 subjects in each group (left and right lobectomies), the V P differences changed from about 2 points before surgery to about 61 2 points after surgery for the left-brain patients and changed from less than one point change before surgery to about 11 2 points after surgery for the right-brain patients Following the lobectomies, left-brain patients dropped about 2 points in Verbal IQ and gained 2 1 2 points in Performance IQ, and right-brain patients evidenced virtually no change in their Performance IQs and gained only 1 point in their Verbal IQs Meier and French (1966) noted that Picture Arrangement scores were especially depressed due to right temporal lobectomy.

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c# itextsharp add text to existing pdf

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